Imagine two little boxes
Computers often store a number in two boxes because one box is not big enough.
Suppose the number is written as:
12 34
Big-endian means the computer puts the most important box first:
[big box] [small box]`n 12 34
Little-endian means it puts the small box first:
[small box] [big box]`n 34 12
Neither one is more correct. They are simply two different ways to line up the same two boxes.
Why screens care
A colour pixel can be packed into two bytes using RGB565. The first byte contains part of the colour and the second byte contains the rest.
If the screen expects big-endian but the computer sends little-endian, the screen reads the two bytes backwards. It is like reading a word by looking at the letters in the wrong order. The picture still appears, but the colours can look very strange.
The tiny rule
Before sending a two-byte pixel, ask:
Does this screen want the big box first or the small box first?
For this display, the ESPHome image is configured as RGB565 with big_endian byte order. That tells the firmware to send the two pixel bytes in the order the display expects.
A friendly takeaway
Big-endian is not a scary computer monster. It is just:
Put the biggest part first.
Little-endian is:
Put the littlest part first.
The important thing is that both the sender and the receiver agree.